p Kevin M. Clare

Kevin M. Clare Curriculum Vitae

Contact Information

Phone: (631) 621-6236
Email (Personal): kevmarclare@gmail.com
Email(Academic): kclare@student.touro.edu

Higher Education

Medical School class of 2023: New York Medical College, Valhalla New York

Bachelor of Engineering: Stony Brook University, New York in the Spring of 2017

Positions and Internship

Laboratory Research

  1. Stony Brook University: Dr. Congwu Du

    Time Period: December 2013 to Present

    Since enrolling at Stony Brook University in the fall of 2013, I have been working in the laboratory of Dr. Congwu Du and Dr. Yingtian Pan studying the hemodynamic and neuronal response of the brain to cocaine. My early work focused on the effect of this drug on astrocytes and the molecular mechanism driving angiogenesis in response to cocaine-related transient ischemic attacks. Recently, my studies have shifted to using a mouse Cre-lox system to probe the effect of cocaine on the two subpopulations of dopamine neurons using a viral injection of GCaMP. To study the response to cocaine, I have used unique imaging modalities such as optical coherence tomography, laser Doppler, and hyperspectral imaging.

  2. Jackson Laboratory: Dr. Gregory Cox

    Time Period: June 1, 2013 to August 12, 2013

    Over the summer of 2013, I was accepted into the Jackson Labs Summer Student Program, where for 10 weeks, I worked under PI Dr. Gregory Cox studying a mouse model of ALS with a TDP43 mutation. After deriving motor neurons from the embryonic stem cells of this mouse model, I tested the effect of angiogenin on the accumulation of TDP43 aggregates. This was done using immunochemistry and fluorescent microscopy to look at the number and size of aggregates at multiple time points and with different amounts of angiogenin. At the end of the ten weeks, I submitted a paper and gave a presentation on my research.

  3. Columbia University Motor Neuron Center: Dr. Diane Re

    Time Period: summer 2011 and summer 2012

    As a high school intern during the summer of 2011 and 2012, I conducted research under the direction of Dr. Diane Re, on the identification of accessory proteins associated with death receptor 6. During this research, I developed my skills in Co-immunoprecipitation, western blotting, cell extraction, embryonic stem cell cultures and embryonic stem cell differentiation into motor neurons. I also performed weekly cell disassociations from mice embryo cortex and spinal cord.

Shadowing

  1. Columbia University Neurological Institue: Dr. Matthew B. Harms

    Time Period: January 2017

    In January of 2017, I shadowed Dr. Matthew B. Harms in multiple medical clinics where I learned about a variety of neuromuscular and neurological diseases with a focus on the genetics of each disease. Also, during the multi-disciplinary clinic for ALS patients, I saw how each member of the team; speech pathologist, social worker, occupational and physical therapist worked with the patient and how the team worked together to ensure the best level of care. This included using genetics to assist in making a diagnosis and choosing a treatment. In addition to the clinics, I also attended Grand Rounds and Clinical Neuromuscular Rounds with Dr. Harms as well as any sessions during which Dr. Harms taught medical school students.

Academic Awards, Prestigious Internships and Honor Societies

Academic Recognition

  1. Received Undergraduate Recognition Award for Academic Excellence from Stony Brook University April 2017.
  2. Graduated Magna Cum Laude from Stony Brook University May 2017.
  3. Awarded departmental honors in biomedical engineering from Stony Brook University May 2017.

Prestigious Internships

  1. Summer 2017 I was accepted for a second time into the National Institute of Drug Abuse (NIDA) Summer Research Internship Program.
  2. Summer 2015 I conducted research as part of the National Institute of Drug Abuse (NIDA) Summer Research Internship Program.
  3. Summer 2013 I was one of thirty students accepted into the Jackson Laboratory Summer Student Program.

Honor Societies

  1. Inducted into the Alpha Eta Mu Beta Biomedical Engineering Honor Society in 2015.

Publications, Presentations, Poster, and Acknowledged Contributions

Publications

  1. Chelsea Pan, Kevin Clare,Optical Imaging of Prefrontal Deficits Induced by Cocaine: Neurons vs Dopamine D2-receptor Expressing Neurons. Proceedings of SPIE Photonics West, San Francisco, CA, February 1-6, 2020: Clinical and Translational Neurophotonics.
  2. Wei Yin, Kevin Clare, Qiujia Zhang, Nora D. Volkow, Congwu Du, Chronic cocaine induces HIF-VEGF pathway activation along with angiogenesis in the brain, PLOS ONE, 2017
  3. Jiang You, Nora Volkow, Kicheon Park, Qiujia Zhang, Kevin Clare, Congwu Du, Yingtian Pan, Cerebrovascular adaptations to cocaine-induced transient ischemic attacks in the rodent brain, JCI Insight, 2017

Presentations

  1. Clare, Kevin.Optical Imaging of Prefrontal Deficits Induced by Cocaine: Neurons vs Dopamine D2-receptor Expressing Neurons. Clinical and Translational Neurophotonics, SPIE Photonics West, February 4, 2020, Moscone Center, San Francisco, CA.

Posters

  1. Kevin Clare, Congwu Du Optical Imaging of Prefrontal Deficits Induced by Cocaine: Neurons vs Dopamine D2-receptor Expressing Neurons New York Medical College Annual Medical Student Research Forum; 2020 Feb 6; Valhalla, NY.
  2. Kicheon Park, Kevin Clare, Weiguo Zhong, Yingtian Pan, Congwu Du, Optical Imaging of the Brain Connectivity: Prefrontal Cortex Response to Deep Brain Stimulation, Stony Brook BME Annual Research Day; 2018 Aug 22; Stony Brook, NY.
  3. Brandon Zhuang, Amna Haider, Hyunsun Shin, Kevin Clare, Craig P. Allen, Gabriel Pagnotti, Congwu Du, Clinton T. Rubin, M. Ete Chan, Rapid decrease in the cortical bone mineral density in response to the intake of cocaine, Biomedical Engineering Society Annual Meeting; 2016 Oct 5-8; Minneapolis, MN.
  4. Amna Haider, Brandon Zhuang, Hyunsu Shin, Kevin Clare, Craig Allen, Gabriel M. Pagnotti, Congwu Du, Clinton T. Rubin, M. Ete Chan, Continuous cocaine administration results in significant Trabecular Bone Deterioration, Biomedical Engineering Society Annual Meeting; 2016 Oct 5-8; Minneapolis, MN.
  5. Sowmya Sudaresh, Qiujia Zhang, Kevin Clare, Nora Volkow, Congwu Du, Chronic Cocaine Decreases GFAP of Astrocytes in Rat Brain Characterized by Optical Imaging, Society for Neuroscience; 2014 Nov 15-19; Washington, DC.

Acknowledged Contributions

  1. Kicheon Park, Wei Chen, Nora D. Volkow, Craig P. Allen, Yingtian Pan, Congwu Du, Hemodynamic and neuronal responses to cocaine differ in awake versus anesthetized animals: Optical brain imaging study, Neuroimage, 2018
  2. Xiaochun Gu, Wei Chen, Nora D. Volkow, Alan P. Koretsky, Congwu Du, Yingtian Pan. Synchronized astrocytic Ca2+ response in neurovascular coupling during somatosensory stimulation and for the resting state, Cell Reports, 2018
  3. Craig P. Allen, Kicheon Park, Ang Li, Nora D. Volkow, George F. Koob, Yingtian Pan, Xiu-Ti Hu, Congwu Du,Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: Optical imaging study in anesthetized rats, Addiction Biology, 2018
  4. Xiaochun Gu, Wei Chen, Jiang You, Alan P. Koretsky, Nora D. Volkow, Yingtian Pan, Congwu Du, Long-term multi-modal optical imaging of neurovascular coupling in neuronal populations at single cell and vessel resolutions, Cell Report, 2018
  5. Qiujia Zhang, Jiang You, Nora D. Volkow, Jeonghun Choi, Wei Yin, Wei Wang, Yingtian Pan, Congwu Du, Chronic cocaine disrupts neurovascular networks and cerebral function: Optical imaging studies in rodents, Journal of Biomedical Optics, 2016

Mentoring in Research, Organizations and Community Involvement

Mentoring in Research

The countless hours my mentors have spent teaching me about neuroscience and how to conduct basic science research played a crucial role in my life. Therefore, as part of my mission as a researcher, I strive to teach the next generation of scientists and engineers. To date, I have introduced and mentored seven students in neuroscience research. These students include: four undergraduates students from Stony Brook University, two high school students, and one Stony Brook University Master's student.

Organizations and Community Involvement

  1. Team Packard (formerly A Mid-Winter Night's Dream)

    Time Period: Fall 2012 to Present

    • Annual Fundraising Gala

      During the Spring 2013 Gala, I managed a team of four students to prepare displays for each donated item gather for the silent auction room. At the completion of the event, the silent auction raised over $40,000 for ALS research. This is part of the 3.7 million dollars in funds this organizations has raised to help support ALS patients and research.

    • Team Packard Stem Challenge

      In the fall of 2014 AMND joined with the Robert Packard Center at Johns Hopkins and thus changed the name to Team Packard. For the last two years, I have assisted in organizing and running part of the annual Team Packard STEM (Science, Technology, Engineering and Mathematics) Challenge for students in grades 4 through 8. In 2017, I helped run the Electronics Snap Circuit challenge where students use their understanding of electronic circuits to complete challenges. In 2018, I facilitated the forensic event in which students used their ability to critically analyze a situation to solve the mystery. During these challenges, I supervised the students and assisted them in collaborating while problem solving.

  2. Biomedical Engineering Society (BMES)- Journal club

    Time Period: Fall 2015- Fall 2018

    One of the toughest aspects for a new student entering into the field is often learning how to comprehend the jargon filled scientific publications. To assist students in this task, I was asked to be part of the team that ran the first Biomedical Engineering Society Journal Club at Stony Brook University. Having had participated in multiple Journal Clubs, I helped to create the format that we would follow for each meeting and I presented the first article for discussion. We also reach out to publishing organizations such as Elsevier to come to Stony Brook and describe the process of submitting and editing articles for publication.